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- Pirates activate 1B Spencer Horwitz from the injured list and send him to Double-A for a rehab assignment (4/27/2025)
- Cardinals activate 3B Noah Mendlinger (AA) from the 7-day injured list (4/24/2025)
- Southern Maryland Blue Crabs of the independent Atlantic League release OF/IF Asaf Lowengart (4/24/2025)
- Cincinnati Reds activate LHP Evan Kravetz at Triple-A (4/20/2025)
- White Sox call up LHP Jared Shuster from Triple-A (4/19/2025)
- Lexington Legends of independent Atlantic League release LF/2B Robb Paller (4/19/2025)
- Cardinals sign free agent C Andy Yerzy, assign him to Triple-A (4/18/2025)
- Gastonia Ghost Peppers of independent Atlantic League sign and activate OF Dalton Guthrie (4/17/2025)
- Phillies promote C Jordan Dissin to Double-A (4/16/2025)
- Reds release C Andy Yerzy from Double-A (4/14/2025)
- Cardinals place 3B Noah Mendlinger (AA) on 7-day injured list (4/12/2025)
- White Sox activate SS Shawn Goosenberg on Double-A team (4/12/2025)
- New York Boulders of the independent Frontier League trade OF David Vinsky to the Trois-Rivières Aigles (4/10/2025)
- Red Sox send RHP Robert Stock outright to Double-A (4/10/2025)
- Red Sox designate RHP Robert Stock for assignment (4/8/2025)
- Red Sox call up RHP Robert Stock from Triple-A (4/7/2025)
- Marlins promote 3B Michael Snyder to High-A (4/3/2025)
- Nationals reassign C CJ Stubbs to Double-A (4/2/2025)
- Reds reassign C Andy Yerzy to Double-A (4/2/2025)
- Mets assign RHP Josh Blum to Single-A (4/1/2025)
- Mariners promote RHP Charlie Beilenson to High-A (4/1/2025)
- Yankees promote RHP Harrison Cohen to Double-A (3/31/2025)
- Yankees promote RHP Eric Reyzelman to Triple-A (3/28/2025)
- Cardinals place LHP Rob Kaminsky (AAA) on 7-day injured list (3/28/2025)
- Padres promote RHP Josh Mallitz to High-A (3/27/2025)
- Athletics place 2B Zack Gelof on 10-day injured list (3/26/2025)
- Rangers call-up OF Kevin Pillar from Double-A (3/26/2025)
- Yankees place RHP Scott Effross on 15-day injured list (3/26/2025)
- Mariners call-up 1B Rowdy Tellez from Triple-A (3/25/2025)
- Reds reassign LHP Evan Kravetz to High-A (3/25/2025)
- Phillies option C Garrett Stubbs to Triple-A (3/20/2025)
- White Sox option LHP Jared Shuster to Triple-A (3/14/2025)
- Astros option LHP Colton Gordon to Triple-A (3/12/2025)
- Cardinals assign RHP Tanner Jacobson (High-A) to MLB Spring Training (3/10/2025)
- Phillies option RHP Max Lazar to Triple-A (3/8/2025)
- Boston Red Sox reassign RHP Robert Stock to Triple-A (3/6/2025)
- Texas Rangers reassign OF Kevin Pillar to Double-A (3/5/2025)
- New York Boulders of the independent Frontier League trade UTL Assaf Lowengart to Southern Maryland Blue Crabs of independent Atlantic League (3/4/2025)
- Texas Rangers sign OF Kevin Pillar to a minor-league contract (2/23/2025)
- New York Mets invite RHP Ben Simon (High-A) to Spring Training (2/22/2025)
- New York Yankees invite RHP Harrison Cohen (High-A) to Spring Training (2/22/2025)
- Cincinnati Reds invite LHP Evan Kravetz (AAA) to Spring Training (2/22/2025)
- San Francisco Giants invite RHP Josh Wolf (High-A) to Spring Training (2/22/2025)
- St. Louis Cardinals invite RHP Zack Weiss (AAA) to Spring Training (2/22/2025)
- St. Louis Cardinals invite LHP Rob Kaminsky (AAA) to Spring Training (2/22/2025)
- Seattle Mariners sign free-agent 1B Rowdy Tellez to minor-league contract and invite him to Spring Training (2/21/2025)
- St. Louis Cardinals assign LHP Rob Kaminsky to AAA (2/13/2025)
- 1B Spencer Horwitz (Pittsburgh Pirates) undergoes surgery on right wrist (2/12/2025)
- St. Louis Cardinals sign free-agent LHP Rob Kaminsky to minor-league contract (2/12/2025)
- Los Angeles Dodgers assign 3B Jake Gelof (High-A) to Spring Training (2/20/2025)
- Chicago Cubs invite 3B Chase Strumpf (AAA) to Spring Training (2/20/2025)
- Boston Red Sox sign free-agent 3B Alex Bregman to 3-year, $120-million contract (2/15/2025)
- Minnesota Twins sign free-agent CF Harrison Bader to one-year, $6.25-million contract (2/7/2025)
- St. Louis Cardinals sign free-agent RHP Zack Weiss to minor-league contract and assign him to AAA (1/27/2025)
- Cincinnati Reds sign free-agent C Andy Yerzy to minor-league contract and assign him to Triple-A (1/20/2025)
- New York Boulders of independent Frontier League sign C Jason Agresti (1/9/2025)
- Texas Rangers sign free-agent DH Joc Pederson to 2-year, $37-million contract (12/30/2024)
- Miami Marlins obtain 1B Matt Mervis (AAA) in trade with Chicago Cubs (12/29/2024)
- New York Yankees sign free-agent LHP Max Fried to 8-year, $218-million contract (12/17/2024)
- Cleveland Guardians acquire 2B Spencer Horwitz from Toronto Blue Jays in trade, then trade him to Pittsburgh Pirates on same day (12/10/2024)